Our Approach

Fund Discipline. Pharma Execution.

Too much promising science gets stranded between academic discovery and clinical validation. Perago Bio closes that gap by providing the capital, operators, and development infrastructure needed to advance therapeutic assets through IND, Phase 1, and early proof-of-concept — before traditional company formation is required.

The Virtual Pipeline Model

One Company. Many Programs. Minimal Overhead.

Traditional drug development requires building a separate company around each asset — with its own management team, infrastructure, and burn rate. Perago inverts this model. We centralize the development engine at the company level and treat each program as a separate cost center, not a separate company.

Traditional Model
Perago Model
Separate company per asset
Shared development engine
Full management team per program
Centralized scientific & regulatory leadership
High fixed overhead
Variable cost structure via CRO/CDMO network
Capital tied to single asset
Portfolio-level capital allocation
Slow kill decisions
Predefined go/no-go criteria at each milestone
Sourcing

We Find Science Where Capital Has Not Followed

Perago actively sources therapeutic programs from channels where promising science is systematically undervalued or underfunded. Our network spans academic institutions, early-stage biotechs, pharma divestiture processes, and capital-constrained companies seeking a development partner.

Asset Criteria

Validated MechanismMeaningful preclinical or early clinical data supporting the biological rationale.
Defined Patient PopulationClear indication with an addressable unmet medical need and identifiable patient segment.
Achievable MilestonesA credible path to a value-inflecting clinical or regulatory milestone within our capital envelope.
Partnering PotentialGenuine interest from large pharma or specialty companies at the anticipated partnering stage.
Development Execution

Perago Is the Operator.

The Perago team directly runs development for every program in the portfolio. We own the scientific strategy, regulatory planning, CMC oversight, and program management — executing through a curated network of CROs, CDMOs, and specialist consulting firms. There is no outsourced management layer. Our partners bring the bench capacity; we bring the direction, accountability, and decision-making.

Operator Model

Perago acts as the internal development team across all programs — not as a passive capital allocator. We set the strategy, manage the vendors, and own the outcomes.

Executed Through

Preclinical CROsTox, PK/PD, and efficacy studies
Clinical CROsPhase 1 site management and monitoring
CDMOsGMP manufacturing and CMC execution
Specialist ConsultantsRegulatory, medical, CMC, and FDA strategy

Shared Capabilities

Scientific Strategy
Regulatory Planning & Execution
CMC Oversight
CRO / CDMO Management
Clinical Operations
Project Management
Business Development
Diligence

Rigorous Evaluation Before Every Commitment

Every program undergoes a structured diligence process before capital is committed. We evaluate scientific validity, IP position, regulatory pathway, competitive landscape, and development cost — producing a clear-eyed view of risk-adjusted value before we proceed.

01Scientific ReviewIndependent assessment of the mechanism, preclinical package, and translational rationale.
02IP & Regulatory LandscapeFreedom-to-operate analysis, patent position review, and regulatory pathway mapping.
03Development PlanningDetailed CMC, clinical, and regulatory plan with milestone-based budget and timeline.
04Commercial AssessmentMarket sizing, competitive positioning, and partnering landscape analysis.
05Go / No-Go DecisionInvestment committee review with predefined criteria. Clear decision — no indefinite holding patterns.
The Stage-Gated Playbook

No Capital Without a Gate Memo.

Every program advances through five defined decision gates. Before capital can be allocated to the next stage, the program team must produce a written gate memo — documenting data, rationale, and development plan — which is reviewed and approved by the Investment Committee. Programs that meet criteria advance. Programs that do not are abandoned and replaced. There are no zombie assets.

Gate 0–1Screen & AcquireTranslational fit, competitive landscape, CMC feasibility, and licensing at predetermined terms.
$[Capital Allocation Range]0–12 weeks
Gate 2–3Validate & EnableTargeted translational assays confirm viability. Pre-IND path defined. GLP tox, CMC, and regulatory readiness achieved.
$[Capital Allocation Range]4–18 months
Gate 4Ph1 / POCAdaptive Phase 1 design with biomarker and target engagement endpoints. Early proof of concept established.
$[Capital Allocation Range]12–18 months
Exit / ContinuationMonetization or Spin-OutAt Ph1/POC, assets are positioned for out-licensing, a pharma development partnership, a capital partnership, or outright acquisition. Where no transaction is available at that stage, the program is spun out into a standalone NewCo and capitalized through VC syndication to continue through Phase 2.
$50M – $250M+License · Partnership · Acquisition · NewCo

Kill Criteria

Assets that fail to meet predefined go/no-go criteria at any gate are abandoned and replaced with new prospects. Capital is recycled, not wasted.

Investment Committee

Investment Committee approval is required before any major capital deployment. Gate advancement requires a written gate memo reviewed by the IC.

Value Creation

Multiple Paths to Monetization

Perago programs are developed with a clear exit thesis. We target value-inflecting milestones — typically Phase 1 completion or early proof of concept — that position assets for partnership or sale to large pharma or specialty companies.

Pharma PartnershipsCo-development or licensing agreements with large pharma at Phase 1 or PoC.
Out-LicensingRoyalty-bearing licenses to regional or specialty pharma partners.
Asset SalesOutright sale of a program at a value-inflecting milestone.
NewCo FormationSpin-out of a program into a standalone company for continued development.

Proceeds from asset monetizations may be distributed to shareholders and/or reinvested into the pipeline, subject to board-approved reserves.

Have an Asset to Discuss?

We are actively seeking high-potential therapeutic programs. If you have a program that fits our criteria, we want to hear from you.